Ivermectin: The Far-Right’s Latest Anti COVID 19 Miracle Drug?

Even though it has legitimate use for both man and beast, why is America’s far-right hailing ivermectin as a miracle drug for treating COVID 19?

By: Ringo Bones

America’s far-right had been resisting legitimate COVID 19 vaccines citing unfounded claims that it contains a really tiny micro-chip that can track your exact location. Even though over-use of social media like Tick-Tock is one sure way for your exact location to be tracked online, far-right anti-vaxxers still resort to other non-vaccine based cures for COVID 19, especially ones not approved by the US Food and Drug Administration and the World Health Organization – i.e. hydroxychloroquine. But has a widely used veterinary variant of an anti parasite drug, ivermectin, now the far-right’s latest miracle cure of choice? But first here’s a brief history of how ivermectin was discovered.

This pharmaceutical product has quite an incredible origin story. In the late 1960s, Satoshi Ōmura, a microbiologist at Tokyo’s Kitasako Institute, was hunting for new antibacterial compounds and started to collect thousands of soil samples from around Japan. He cultured bacteria from the samples, screened the cultures for medical potential and sent them ten thousand kilometers away to Merck Research Labs in New Jersey, where his collaborator, William Campbell, tested their effect against parasitic worms affecting livestock and other animals. One culture, derived from a soil sample collected near a golf course southwest of Tokyo, was remarkably effective against worms. The bacterium culture was a new species and was baptized Streptomyces avermictilis. The active component, named avermectin, was chemically modified to increase its activity and safety. The new compound, called ivermectin, was commercialized as a product for animal health in 1981 and soon became a top-selling veterinary drug in the world. Remarkably, despite decades of searching, Streptomyces avermictilis remains the only source of avermectin ever found.

A few years after becoming a best-selling veterinary drug, Campbell urged his colleagues to study ivermectin as a potential treatment for onchocerciasis – also known as river blindness – a devastating disease caused by worms and transmitted by flies that left millions of people blind, mostly in sub-Saharan Africa. The first clinical trials in Senegal showed that the treatment worked and ivermectin was approved for human use in 1987.

As of August 29, 2021, ivermectin, in its horse de-wormer form, was the leading cause of poisoning cases as reported in the United States’ Poison Control hotlines, especially in “farming states” where the former far-right US President Donald J. Trump was very popular. Poison Control Centers across the so-called “red states” received a record number of calls of people suffering side-effects for taking ivermectin without a doctor’s prescription – especially in its horse de-wormer paste and giant pill form.

According to the US Food and Drug Administration, animal / veterinary grade de-wormers are not safe for human consumption. But during the summer of 2021, America’s right-wing media outlets like Fox News and News Max and a few others had been busy promoting ivermectin as a perfectly safe miracle cure for COVID 19.

For those old enough to remember, ivermectin – in the form of veterinary grade horse de-wormers – was widely popularized by many a lothario during the early to mid 1980s as a very effective aphrodisiac. Our neighborhood lothario – who turned 18 back in 1976 - still swears by it as a very effective aphrodisiac despite of the veterinary grade ivermectin posing a health hazard to the human physiology.

Medical Detection Dogs: The Future Of COVID 19 Testing?

They’ve successfully sniffed out different forms of cancers and sniffed out those affected by malaria for years, but are medical detection dogs the future of COVID 19 testing and detection?

By: Ringp Bones

Three months ago, specifically trained medical detection dogs have shown promising results in being able to detect COVID 19 in suspected patients even before the patients tested positive with existing COVID 19 test procedures, thus establishing their potential for use in new non-invasive, early warning measure to detect coronavirus in the future. After promising results by the world leading researchers at the London School of Hygiene and Tropical Medicine (LSHTM) and collaboration with the charity Medical Detection Dogs and Durham University, dogs that can sniff out COVID 19 will soon be working as an early detection system in a public space near you.

Given that dogs have been successfully sniffing out certain cancers and even malaria infected individuals for a number of years now, COVID 19 detection could represent the new frontier for these medical detection dogs. More than 10 years of research gathered by Medical Detection Dogs has shown that the dogs, which could screen up to 250 people per hour, can be trained to detect the odor of specific diseases at the equivalent dilution of one teaspoon of sugar in 2-Olympic sized swimming pools of water.

Trials in Helsinki, Finland’s airports are already planned to use medical detection dogs to “sniff-out” newly arrived plane passengers for COVID 19. And given the promising results by the London School of Hygiene and Tropical Medicine trials of these dogs, the medical detection dogs can also perform mass screenings of COVID 19 at a faster time compared to existing mass testing methods with even better accuracy. This could make the disconcerting cotton swab through the nose testing for COVID 19 a thing of the past.

Could The Oxford Coronavirus Vaccine End The COVID 19 Pandemic?

With extremely encouraging results, could the Oxford Coronavirus Vaccine be the one to end the ongoing global COVID 19 pandemic?

By: Ringo Bones

A senior British official has called the latest news on an Oxford University team’s potential coronavirus vaccine as “extremely encouraging”. The UK Phase I and II trial of the Oxford University coronavirus vaccine began in April 2020 and involved 1,077 healthy volunteers who were between 18 and 55 years old. Some of those volunteers received a second booster dose of the vaccine and they appeared to benefit the most. The vaccine was being developed by Oxford’s Jenner Institute in conjunction with the pharmaceutical giant AstraZeneca, showed that it is safe and produced a strong immune results according to the research published on Monday, July 20, 2020 in The Lancet medical journal.

The Oxford Coronavirus Vaccine is made from a genetically engineered virus that causes the common cold in chimpanzees. The vaccine caused a two-pronged immune response, says a news release from the Jenner Institute at Oxford.  First, within 14 days, it triggered a T-cell response, generating white blood cells that can attack infected cells. Second, within 28 days, it provoked an antibody response. Antibodies are able to prevent the virus from infecting cells when it is initially contracted the disease according to the release. Oxford is working with AstraZeneca to develop, manufacture and produce a coronavirus vaccine on a large scale. The unprecedented effort aims to make some 2-billion doses of the vaccine to be available globally, through partnerships with manufacturers in several countries, by early next year.

Lead scientist Prof. Sarah Gilbert told the BBC on Tuesday, July 21, 2020 that while the hope was still to be able to make millions of doses available by this autumn, there was still “absolutely no certainty” of that timeline, as the final Phase III trials were still ongoing and the roll-out of the vaccine on a large scale was also contingent on the manufacturing process and individual nations’ safety regulators approving it for emergency use. There were no dangerous side effects from taking the vaccine; however, 70-percent of the people on the trial developed either fever or headache.

Are Russian Cyber-Spies Targeting COVID 19 Vaccine Research Labs?

Seems unbelievable when I’ve first heard of it but are Russia’s top cyber-spies targeting the world’s leading COVID 19 vaccine research labs?

By: Ringo Bones

Given that to those old enough to remember that the then Soviet Union was at the cutting edge in medical science when it comes to developing performance enhancing drugs at the height of the Cold War, and hence their “almost mythical” athletic performance during the Olympic Games after World War II, that Putin era Russia now has resorted to stealing vital data via cyber espionage when it comes to developing a working COVID 19 vaccine seems “unbelievable”. But, sadly, the world’s leading cyber security services had just found out that the Kremlin’s go-to cyber-spies, a hacker group popularly known as Cozy Bear, was responsible for hacking the computer servers of UK, Canadian and US labs currently working on a working COVID 19 vaccine. It did not specify which organizations had been targeted or whether any information had been stolen. But it said vaccine research had not been hindered by hackers and as usual, Russia has denied any responsibility.

The warning was recently published by an international group of security services like the UK’s NCSC, the Canadian Communication Security Establishment (CSE), the United States Department of Homeland Security (DHS) Cyber security Infrastructure Security Agency (CISA) and the US National security Agency. One expert said it was “plausible” that, despite the Kremlin’s denials, Russian spies were involved. Cozy Bear – the named cyber espionage and hacking group – has been implicated in past cyber attacks and has left quite a trail, and there are fairly good links to the Russian state itself. Cozy Bear was first identified as being a significant “threat actor” as far back as 2014, according to the American cyber security firm Crowdstrike. It describes the group as being “aggressive” in its tactics and “nothing if not flexible, changing tool sets frequently. The unit has been previously implicated in hacking the US Democratic National Committee (DNC) during the 2016 US Presidential Election. But given Russia’s reputation of being the cutting edge in medical science since the Soviet era, why did the Kremlin authorize such an operation in order to be the first in developing a working COVID 19 vaccine?

From a geopolitical perspective, a nation state that can first develop a working COVID 19 vaccine could gain an unfair advantage from an economic perspective in being able to end a government enforced lockdown and restarting the economy while keeping its own citizens from getting sick and or dying from COVID 19. It seems that the COVID 19 vaccine spy-game is a high stakes play in terms of statecraft indeed. Let’s just hope that Agent 007 has the sufficient medical degree to tackle such a case successfully.

Will There Be A Post COVID 19 Famine?

Given that it has already disrupted food production in sensitive regions of the world will there be more people dying of hunger than of the COVID 19 virus?

By: Ringo Bones

The charity group Oxfam and the United Nations recently issued a warning that more people could eventually die of hunger than from the COVID 19 virus. Starvation warnings are now posted in vulnerable parts of the world and these regions are not necessary, at the moment, experiencing armed conflict. But could starvation eventually take more lives than from the COVID 19 virus?

According to Oxfam, COVID 19 is already disrupting food production in poorer parts of Africa currently not experiencing armed conflict. And basing on recently imposed lockdown measures, COVID 19 could complicate the delivery of food aid and the resulting economic downturn due to the coronavirus lockdown caused runaway unemployment will make charitable fundraising activities much more difficult. The UN says up to 122-millon people worldwide could be facing starvation by the end of 2020. And according to Oxfam, up to 12,000 people a die could die of hunger by the end of 2020. By way of comparison, the global death peak of COVID 19 back in April 2020 was only 10,000 deaths per day, which is quite a sobering statistic any way you put it.

The recent Oxfam briefing also reveals the world’s ten worst hunger hotspots, places such as Venezuela and South Sudan where the food crisis is most severe and getting worse as a result of the COVID 19 pandemic. It also highlights emerging epicenters of hunger – middle income countries such as India, South Africa and Brazil – where millions of people who were barely managing have been tipped over the edge by the pandemic.

Hydroxychloroquine: The Drug Of Choice Of Right Wing Populists?

Given that it is touted by Presidents Donald Trump, Jail Bolsonaro amongst others, is the anti-malarial drug hydroxychloroquine the drug of choice of right wing populists in the treatment of COVID 19?

By: Ringo Bones

Brazilian strongman President Jair Bolsonaro recently used it after recently registering positive for COVID 19 and US President Donald Trump and his far right inner circle – like former NY City Mayor Rudi Giuliani – had been promoting it as an effective cure for the coronavirus. Originally for malaria and lupus, hydroxychloroquine was originally shortlisted by the Solidarity Trial – an international clinical trial launched by the WHO and other partners to help find an effective treatment for COVID 19. It was hoped that one or more treatments under trial, including hydroxychloroquine, will result in improving clinical outcomes in COVID 19 patients and save lives. But hydroxychloroquine trials were eventually stopped as of June 17, 2020 as evidence showed it did not result in the reduction of mortality of hospitalized COVID 19 patients when compared with standard care. Given that it has been proven to do nothing against COVID 19, why is it that some people – especially those in the far right populist wing – still insist that hydroxychloroquine is the only effective cure against COVID 19?

Conspiracy theories tend to be grounded in unusual coincidences or misunderstood science and they use highly emotional language to appeal to others. In a time when public mistrust is at an all-time low, it is important to counter false information with clear, high-quality evidence. Although not a conspiracy theory, the hype around hydroychloroquine started in March 14, 2020 when a Google Word document was circulated on Twitter touting the potential use of repurposing the old anti-malaria drug hydroxychloroquine as a possible COVID 19 cure. The document claimed to be written in consultation with prestigious medical schools and scientific institutions and by March 16 it had gone viral on Twitter. Unfortunately, it was only realized much later that the author of the document was actually a blockchain investor, who had inaccurately claimed to write it in consultation with medical schools and scientists.

The global hype around hydroxychloroquine had already been set in motion before the first clinical study testing it on COVID 19 patients was even published on March 17, 2020 with the study only finding a 50-percent improvement in the extremely small sample size of 14 patients with COVID 19 taking hydroxychloroquine alone. These authors have now been criticized for not randomly assigning patients to treatment groups, their small sample size and lack of a control group to compare with the treatment group with, meaning that the positive results could easily have occurred by chance.

However, by March 19, 2020 – US President Donald Trump, in conjunction with former NYC Mayor Rudi Giuliani, were promoting the potential of the drug at press conferences, incorrectly stating it had already been approved by the US Food and Drug Administration (FDA) to treat the COVID 19 virus. The FDA then had to release a statement cautioning people against using the drug off label. Later, when President Trump stated that he was taking a two week course of hydroxychloroquine, despite any evidence showing it could prevent COVID 19, there was widespread concern from healthcare professionals about the dangerous example this could set. A recent study confirmed a huge surge in hydroxychloroquine and chloroquine prescription fills – likely due to off label prescriptions for COVID 19.

Since then, hospitals now have to deal with the additional burden of treating people poisoning themselves after taking the drug, with one man fatally poisoning himself with a fish tank cleaning additive made with the same active ingredient as chloroquine. The bias towards this drug is even derailing clinical trials of other closely related COVID 19 treatment regimens. While studies done within cell dishes in labs show that both hydroxychloroquine and chloroquine can inhibit the virus, as with any medicine while studies in humans tend to be much more inconsistent. The largest study of the drug was published in The Lancet on May 22, 2020 stating that the drug increased the risk of death in hospitalized COVID 19 patients. This paper has now been famously retracted because of serious concerns about the verification of the data sources, study design and analysis used. While the verdict on hydroxychloroquine is far from clear, now is not the time for anyone to be taking this drug off label.

Air Pollution: Anathema To COVID 19 Sufferers?

Given that they already have compromised respiratory systems, does COVID 19 sufferers in cities with high levels of air pollution more likely to die that their counterparts in clean air locales?

By: Ringo Bones

Public health policymakers have been warning us for decades that polluted air is a serious threat to people with compromised respiratory systems – like ones suffering from asthma and related preexisting chronic lung conditions. Since the year 2000, about a million people die annually in Mainland China’s urban centers where the air quality falls far below the acceptable guidelines set by the World Health Organization. But since the advent of the COVID 19 pandemic, does polluted air spell the death knell to COVID 19 sufferers?

A recently published research from the Harvard University School of Public Health shows that COVID 19 sufferers living in cities with severe levels of air pollution are more likely to die than ones living in regions with much cleaner air. Even though pollution levels in cities have declined since lockdown measures were enforced. Polluted cities COVID 19 death rates are up to a third higher compared to cities with cleaner air and stricter enforced clean air policies.

Given that the Trump administration had rolled back the EPA’s Clean Air Act back in 2017, the increased levels of COVID 19 deaths in the United States could be attributable to increased pollution levels in major metropolitan areas. The Harvard study now highlights the importance of clean air laws when it comes to formulating public health policy.